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KMID : 0382619820020020251
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Hanyang Journal of Medicine
1982 Volume.2 No. 2 p.251 ~ p.259
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EFFECT OF INTRAHYPOTHALAMICALLY INJECTED TETRODOTOXIN ON THE ARTERIAL BLOOD PRESSURE.
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Abstract
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The present study was undertaken to investigate the effect of tetrodotoxin (TTX) on excitability of the hypothalamus to electrical stimulation and to find out. if the hypothalamus has any tonic activity on the cardiovascular system by observing changes in blood pressure and heart rate after intrahypothalamic administration of TTX. The results obtained are as follows:
1. After intrahypothalamic administration of 0.005μg/Kg and 0.01μg/Kg tetrodotoxin, the pressor responses to electrical stimulation of the hypothalamus were gradually reduced and at dosage of 0.O1μg/Kg TTX the responses were almost abolished 30 seconds to 3 minutes after TTX administration.
2. After 0.005μg/Kg TTX administration arterial blood pressure and heart rete decreased significantly at 20 minutes and 15 minutes after TTX administration respectively.
3. In the cases O.Ol jsg/Kg TTX was administered, significant decrements in blood pressure and heart rate were observed respectively at 15 minutes and 10 minutes after TTX administration.
4. Since there were no significant decreases in blood pressure and heart rate immediately after tetrodotoxin administration, it is strongly suggested that the hypothalamus has no tonic activity to the cardiovascular system.
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KEYWORD
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